Update 'Low-Degree Carbon Monoxide Exposure Affects Bold FMRI Response'

Low-Degree-Carbon-Monoxide-Exposure-Affects-Bold-FMRI-Response.md

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+<br>Blood oxygen level dependent (Bold) fMRI is a common technique for measuring brain activation that may very well be affected by low-stage carbon monoxide (CO) exposure from, e.g. smoking. This study aimed to probe the vulnerability of Bold fMRI to CO and decide whether it may constitute a significant neuroimaging confound. Low-level (6 ppm exhaled) CO results on Bold response were assessed in 12 wholesome by no means-smokers on two separate experimental days (CO and air management). MRI tasks were breath-holds (hypercapnia), visual stimulation and fingertapping. Bold fMRI response was decrease during breath holds, visual stimulation and fingertapping in the CO protocol compared to the air control protocol. Behavioural and physiological measures remained unchanged. We conclude that Bold fMRI is perhaps susceptible to adjustments in baseline CO, and counsel exercising caution when imaging populations uncovered to elevated CO ranges. Further work is required to fully elucidate the affect on CO on fMRI and its underlying mechanisms.<br>
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